The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
9 Celebrities Whose Bodies Are Close to Perfection, According to Science
For ages, the golden ratio, also known as the divine proportion, has fascinated creative minds like artists, architects, and mathematicians. Its mysterious presence in both nature and art adds to its allure. When applied to the human body, this ratio highlights certain proportions that are considered visually appealing. While this mathematical formula suggests ideal proportions, what truly inspires us are the stories, personalities, and accomplishments of the individuals embodying these proportions.
9. Salma Hayek — 88%
Salma Hayek’s beauty is like a beautiful melody composed of various enchanting elements that come together effortlessly, creating a timeless charm that never fades. Her unique features, including her intense gaze and graceful smile, exude both sophistication and liveliness. However, her beauty isn’t just skin deep; it’s also reflected in her unwavering confidence.
This confidence shines through, adding to her external allure and making her a captivating presence in the world of beauty. Whether she’s on-screen or attending public events, Salma Hayek’s beauty is a perfect blend of her individuality, magnetic personality, and enduring elegance, captivating people’s hearts around the globe.
8. Elle Macpherson — 88.3%
Elle Macpherson is celebrated for her enduring beauty and impressive figure. With her glowing complexion, striking blue eyes, and iconic blond hair, she embodies elegance. Yet, her beauty isn’t solely skin deep. Macpherson’s dedication to health and fitness plays a significant role in maintaining her remarkable physique. As both a thriving model and entrepreneur, she serves as an inspiration by promoting a holistic approach to beauty, emphasizing the significance of nurturing both inner and outer wellness.
7. Cameron Diaz — 91%
Cameron Diaz embodies a lively and genuine beauty that connects with people on a deep level. Her contagious smile, lively eyes, and beautiful blonde hair are what make her stand out. But it’s not just her looks that draw people in; Diaz’s confidence and down-to-earth nature add to her charm. As a well-known actress and supporter of body positivity, she encourages others to embrace their individuality. Diaz’s beauty isn’t just skin deep; it reflects authenticity and self-confidence, which is truly captivating and motivating for many.
6. Katy Perry — 92%
Katy Perry embraces a beauty that’s all about being yourself without apology. Her unique style includes hair colors that range from bold blue to striking purple, reflecting her fearless creativity. Her eyes convey a range of emotions, and her smile lights up the room, making her truly captivating. Perry’s charm comes from her willingness to try different looks while staying true to who she is.
She advocates for body positivity, standing against unrealistic beauty standards. Perry’s beauty goes beyond her appearance; it’s about the confidence she exudes, the empowering messages she spreads, and the creativity that makes her stand out in a world where being genuine is valued.
5. Kelly Brook — 92.9%
Kelly Brook embodies a beauty that goes beyond stereotypes. Her curvy body and confident demeanor challenge narrow standards, inspiring others to embrace themselves fully. With her flowing brunette hair and timeless charm, she exudes elegance. Brook’s acceptance of her natural curves encourages others to do the same.
Her beauty isn’t just about looks; it’s about authenticity. In a world obsessed with perfection, she shines with genuine warmth and charisma. Brook proves that true beauty is about being yourself and feeling confident.
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4. Marilyn Monroe — 94%
Marilyn Monroe remains an enduring symbol of beauty that transcends generations. Her iconic platinum blonde hair and glamorous red lips epitomize the allure of old Hollywood. But Monroe’s beauty goes beyond her appearance; it’s her confidence and vulnerability that truly brought her charm to life.
Her curvaceous figure challenged the beauty standards of her time, reshaping perceptions of femininity. Monroe’s beauty is more than skin deep; it symbolizes empowerment and embracing one’s sensuality without hesitation. In a world where trends come and go, her legacy reminds us that real beauty is about embracing who you are, exuding self-assurance, and possessing a timeless charisma that never fades.
3. Helen Mirren — 95.6%
Helen Mirren embodies a beauty that goes beyond age and expectations. Her silver hair, elegantly framing her poised demeanor, reflects her acceptance of the passage of time. With eyes that sparkle with wisdom and a warm smile that tells stories of a fulfilling life, Mirren’s beauty shines from within. She challenges society’s norms by proving that beauty isn’t limited to youth; it blossoms with maturity.
Mirren’s authenticity and refusal to conform to narrow beauty standards redefine what it means to be beautiful. Beyond her stunning appearance, her inner strength and intelligence illuminate her presence. Mirren’s beauty is a symbol of confidence, embracing life’s journey, and a reminder that true allure is a unique expression of individuality that evolves over time.
2. Kim Kardashian — 96.3%
Kim Kardashian represents a modern kind of beauty that has made a huge impact on popular culture. Her perfect makeup, defined features, and toned body have set new standards in the beauty and fashion world. With captivating eyes that show both vulnerability and strength and her distinctive dark hair, Kardashian’s appeal lies in her ability to constantly evolve while still being unmistakably herself. She’s changed the way we see body shapes, embracing her curves and celebrating her uniqueness. Kardashian’s beauty is all about owning your power, confidently pushing boundaries, and setting trends that resonate with millions.
Beyond just looks, her entrepreneurial drive and influence show that beauty can lead to success. Whether it’s through makeup or expressing herself, Kardashian’s beauty story is a mix of boldness, individuality, and a pioneering spirit that has reshaped the idea of modern allure.
1. Scarlett Johansson — 96.4%
Scarlett Johansson embodies a beauty that remains captivating through different time periods. Her husky voice and mesmerizing gaze give her an irresistible charm that lasts. Her blonde hair frames a face that effortlessly switches between innocence and strength. Johansson’s beauty can’t be easily defined, as she effortlessly moves between classic elegance and edgy appeal.
But there’s more to her than just looks. Her roles in movies and her advocacy work show her intelligence and compassion. She’s changed the idea of what it means to be a modern woman by embracing her identity and fighting for gender equality. Johansson’s beauty isn’t just about what you see on the surface; it’s a complex mix of versatility, depth, and empowerment that continues to influence how people see beauty and inspires respect.
A survey was conducted to determine the 20 most beautiful women of all time. Among the top three, Marilyn Monroe claimed the 3rd spot, while Grace Kelly secured the 2nd position. As for the first place, you’ll have to read the article to uncover the winner.
Preview photo credit salmahayek / Instagram, ScreenProd / Photononstop / Alamy Stock Photo, Scoop / BBC Films and co-producers
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