Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
High fever Excessive night sweats Extreme fatigue Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
Severe swelling in lymph nodes (especially in the neck) CT scan abnormalities indicating TB inflammation Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
Severe chills and fever Uncontrollable night sweats Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
High-dose intravenous (IV) steroids for five days to calm the immune system A slow transition to oral steroids for three months Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot. Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications. Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
Myocarditis (heart muscle inflammation) Pericarditis (inflammation around the heart lining) Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
Joyce DeWitt’s Candid Confession Confirms What We All Suspected
Decades may have passed since Three’s Company graced our screens, but its laughter still echoes in our hearts.
With unforgettable characters and side-splitting misunderstandings, this classic sitcom revolutionized the genre. Now, Joyce DeWitt reveals what really made the show a timeless treasure…
Public Domain
From the hilarious antics of three single roommates to the unforgettable performances of John Ritter and Suzanne Somers, Three’s Company remains a beloved staple of American television. It’s hard to believe it’s been 40 years since the series finale aired on ABC, yet its charm and humor still resonate today.
To illustrate how long ago Three’s Company became a hit, I just watched the intro. Seeing the shots from Santa Monica Pier during the show’s prime reminds me of how much has changed since they filmed there.
Sadly, neither John Ritter nor Suzanne Somers are with us anymore; both were taken from us far too soon. But keeping the spirit of Three’s Company alive is Joyce DeWitt, 75, who shares her vibrant stories and cherished memories from the beloved show.
”The most dear, precious, tender – and utterly unexpected – experiences that have come from working in ‘Three’s Company’ are the many, many adults who have told me that ‘Three’s Company’ was a safe haven they could count on during their teen years – for some, the only safe haven,” Joyce DeWitt told US Weekly.
Joyce DeWitt circa 1978. (Photo by Images Press/IMAGES/Getty Images)
Starring as Janet Wood alongside John Ritter and Suzanne Somers, DeWitt became a television icon and she was such a day brightener for millions.
She appeared in 171 episodes of the show between 1976 and 1984.
“It was such a gift. I mean, it was iconic. But who would have thought it?” Joyce DeWitt told The Spec. “All we were trying to do was make people laugh. When I think about it, the show was really an attempt to do a contemporary version of a 16th-century farce. It was about silliness running wild. I mean, we were talking about serious issues at times, but that was always somewhere underneath.”
“John Ritter used to say, ‘We don’t want people to just laugh but to fall over their couch laughing,’” she added. “The real issue was always the depth of friendship and the love those characters had for each other. That’s what drew people to them.”
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After Three’s Company ended, DeWitt stepped away from the spotlight for over a decade before making her comeback to acting.
Yet, no matter what she has accomplished or plans to do in the future, the vast majority will always connect her with that iconic show. And there’s a very simple reason for that, according to DeWitt.
“It was a ‘time out’ from the oppressive, challenging, difficult circumstances they were navigating in their young lives,” DeWitt says and adds:
“And, oh by the way, they say the characters also did stupid, crazy stuff that made them laugh. But it was the love, trust and support of the characters, one to the other, that made them lifelong fans.”
Public Domain
When you look at unedited photos from the Three’s Company set, the camaraderie among the cast shines through, especially in the images of Joyce DeWitt and Suzanne Somers, who played the beloved Chrissy Snow.
Both actresses delivered iconic performances, portraying young women navigating a male-dominated industry. They contributed just as much to the show’s success as John Ritter, and in those early days, their smiles in photos tell a story of friendship and collaboration.
Yet, beneath the laughter, tensions simmered. While Somers was celebrated for her role as “the dumbest blonde in America,” her fight for equal pay created rifts that would grow over time. As she demanded a 500% salary increase — from $30,000 to $150,000 — her relationship with DeWitt became strained. The set, once filled with joy, was now fraught with conflict.
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