The topic of what constitutes a lasting and prosperous marriage has been a subject of ongoing discussion. While effective communication is often considered a crucial factor, a Japanese couple defied expectations by maintaining a 20-year marriage without saying a word. The surprising rationale behind their silent union adds an intriguing twist to their story.
A Japanese husband took the “silent treatment” to a whole new level.
The silent treatment entails the refusal to participate in verbal communication when someone is trying to engage and elicit a response. It is not unusual to observe a pause in communication following an argument.
However, can you imagine the difficulty of being married to a spouse who persistently avoids communication? This was the situation for a couple from the Nara region in Japan. Otou Katayama and his wife Yumi faced a prolonged two-decade rough patch in their relationship.
For decades, the man refrained from speaking to his wife, even though they lived under the same roof.
Otou Katayama continued to reside with his children and wife. Despite Yumi Katayama’s attempts to initiate conversations with her husband, she consistently faced a dearth of genuine responses. Instead, Otou communicated approval or disapproval through non-verbal cues, relying on grunts and nods.
Surprisingly, the idea of seeking a divorce or separation never crossed the wife’s mind. The couple even extended their family by welcoming a third child, all while Otou Katayama maintained his silent demeanor towards his wife.
The reason behind Katayama’s silence is even more surprising.
Years later, the father and husband elucidated the reasons behind imposing a 20-year silent treatment on his wife. Katayama believed he was lacking the attention he desired from his wife, feeling that her care was predominantly focused on their children.
Initially, he merely sulked about the situation, but over time, this evolved into a sense of jealousy toward his kids and his wife, who exhibited deep involvement in the upbringing of their offspring—perhaps a level of involvement that exceeded Katayama’s preferences.
Thanks to a TV show, husband and wife finally exchanged words after 20 years.
After two decades of silence, the adult children of the Japanese couple decided to take matters into their own hands. They approached a TV show, seeking assistance in resolving the longstanding conflict between their parents. TV Hokkaido stepped in to help the children witness Katayama speaking to his wife for the first time.
The children confessed that they couldn’t recall ever hearing a conversation between their parents. TV Hokkaido orchestrated a meeting between Otou and Yumi at a park, the same location as their first date many years ago. Unbeknownst to the spouses, their children, along with the audience, observed the emotional moment unfolding before their eyes.
After some initial hesitation, Otou Katayama finally mustered the courage to speak a few words to his wife, Yumi. In that moment, the husband felt a heightened sense of remorse and understanding regarding the situation. Katayama conveyed to his wife that he was aware of the pain and hardship his prolonged silence had caused her. Despite his regret, he also expressed gratitude to Yumi for standing by him throughout two decades of his silent period, which ultimately came to an end on that day.
Undoubtedly, the relationship between Otou and Yumi is distinctive, much like that of the couple from our previous article who, despite the woman’s disability and the criticism they faced, embarked on the journey of starting a family and became parents.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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